Press Releases
Bioneer Leads Innovation in Gene Synthesis with Development of 100kb-Scale DNA Synthesis Technology
관리자 / 2025-05-26
Bioneer Leads Innovation in Gene Synthesis
with Development of 100kb-Scale DNA Synthesis Technology
Bioneer, a leading biotechnology company with over 30
years of expertise in molecular and synthetic biology, announced on May 26 that
it has developed a new gene synthesis technology capable of precisely
synthesizing and assembling DNA sequences up to 100 kilobases (100kb) in
length.
This breakthrough technology focuses on accurately
synthesizing up to 100,000 base pairs of DNA from short oligonucleotides and
assembling them into long, continuous sequences. It is expected to open new
frontiers in high-throughput gene synthesis and complex genome design.
The 100kb DNA synthesis technology is built on
Bioneer’s proprietary high-efficiency platform, which leverages internally
produced key raw materials to ensure both high quality and cost
competitiveness. With this advancement, Bioneer is now equipped to offer
groundbreaking solutions for large-scale genome projects and synthetic biology
researchers working with intricate DNA constructs.
Alongside the development of this new technology,
Bioneer has also enhanced its advanced synthesis capabilities and services. Its
proprietary oligo design technology, which boasts an initial fragment assembly
success rate of over 99%, overcomes concentration variation challenges during
synthesis and maximizes small-fragment assembly efficiency. This innovation
also supports the development of a fully automated gene synthesis process
utilizing artificial intelligence, aiming to establish a system capable of
producing thousands of initial fragments with minimal human intervention.
To synthesize DNA structures of up to 100kb, Bioneer
employs a combination of advanced techniques, including Gibson Assembly, its
own proprietary fragment assembly methods, and in vivo assembly. Multiple
fragments can be assembled simultaneously with high efficiency. The final
synthesized genes are verified with 100% accuracy through single-colony Sanger
sequencing, and a range of additional services is offered, such as custom
vector cloning and mRNA synthesis.
Through the launch of its 100kb DNA synthesis
technology, Bioneer aims to meet the diverse needs of researchers in academia,
biotechnology, and the pharmaceutical industry worldwide, reinforcing its
leadership in synthetic biology innovation. According to a 2024 report by
global market research firm Data Bridge Market Research, the global gene
synthesis market is valued at USD 3.25 billion in 2024 and is projected to grow
at a compound annual growth rate (CAGR) of 22.9% from 2025 to 2032.
A company representative stated, “The development of
this 100kb synthesis technology marks a significant milestone in our efforts to
help researchers handle larger and more complex genetic information quickly and
cost-effectively. The ability to accurately synthesize numerous short DNA
fragments and assemble them into long, desired sequences will greatly expand
the potential of synthetic biology.” ###